Sample size determination for clinical research
نویسندگان
چکیده
منابع مشابه
Sample size determination for logistic regression
The problem of sample size estimation is important in medical applications, especially in cases of expensive measurements of immune biomarkers. This paper describes the problem of logistic regression analysis with the sample size determination algorithms, namely the methods of univariate statistics, logistics regression, cross-validation and Bayesian inference. The authors, treating the regr...
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In this paper we introduce a stochastic optimization method based ona mixed Bayesian/frequentist approach to a sample size determinationproblem in a clinical trial. The data are assumed to come from a nor-mal distribution for which both the mean and the variance are unknown.In contrast to the usual Bayesian decision theoretic methodology, whichassumes a single decision maker, our method recogni...
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Background and purpose: Sample size and its determination is one of the most important problems in health researches. Calculating sample size for prevalence studies is one of the common questions of sample size topics. Minimum sample size with least complexity is desirable in order to achieve the basic goal of these studies. This study aims to compare two formulas of sample size calculation for...
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A decision theoretic framework for sample size determination for a clinical trial is presented in which the nal decision whether to use the new treatment is taken by potential users and their medical advisers on the basis of the strength of the evidence provided by the trial. This is more realistic than the usual decision theoretic assumption that both the sample size and terminal decisions are...
متن کاملSample size calculations in clinical research.
The specific goal of this (2nd edition) book continues to be to provide a comprehensive and unified presentation regarding sample size calculations in a variety of clinical research and development phases and to serve as a solid reference for researchers in academia, industry, and government. The book has been expanded, by around 100 pages, from its original 12 chapters to its current 15 chapte...
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ژورنال
عنوان ژورنال: Muscle Ligaments and Tendons Journal
سال: 2019
ISSN: 2240-4554
DOI: 10.32098/mltj.03.2013.01